Nitric Oxide - A ROBUST Signaling Molecule

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Nitric Oxide - A ROBUST Signaling Molecule

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In 1998 the Nobel prize in physiology was jointly awarded to three scientists, Robert F. Furchgott, Louis J. Ignarro, and Ferid Murad, for their discovery of nitric oxide (NO) as a signaling molecule in the heart. The significance of NO's discovery can't be understated. What had been, prior to its discovery in the human body, considered an environmental pollutant is currently known to be one of the important molecules in the body. In his speech at the Nobel Prize Ceremony, Professor Sten Lindahl had this to say concerning the discovery: "Your discoveries concerning nitric oxide as a signaling molecule in the heart, have not only explained the working principle of a vintage important group of drugs, the nitrovasodilators, it has also opened new avenues for patient treatment and diagnoses of varied diseases. Your discoveries have lifted medical research into a new era."

What is it?

NO is really a highly reactive gas that's naturally produced in the body. It affects various physiological functions including circulation, inflammation, learning and memory, digestion, penile erection, and oxygen release in tissues from red blood cells. It really is produced in your body through the conversion of L-arginine (an amino acid) by NO synthase. The process of aging decreases your body's capability to produce nitric oxide and for that reason, many people lack in nitric oxide production. Lower production of Nitric Oxide that results from age is responsible for many ailments faced in modern society.

What does it do?

NO has a selection of physiological roles within the body, but its most significant role is in the relaxation of the smooth muscles in the artery (vasodilation). The opening of arteries permits an increase of blood circulation around the body. This increases the efficiency of which nutrients and molecules can travel to sites of importance. Lower degree of NO in your body as a result of age have the effect of a number of different diseases including: atherosclerosis, peripheral artery disease, stroke, hair loss, erection dysfunction, diabetes, and pain.



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